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Comparison

DEET vs Picaridin vs Permethrin

Three different chemicals doing three different jobs. Two go on skin; one never should.

Written by William • Updated August 2026 • 6 min read

These three products get grouped together and are not interchangeable. DEET and picaridin are skin-applied repellents that keep insects from landing. Permethrin is a clothing treatment that kills ticks on contact and must never be applied to skin. Used together they cover more than either alone.

  1. 1

    DEET: the long-established repellent

    DEET has decades of use behind it and works against mosquitoes, ticks, and biting flies. Higher concentrations extend duration rather than increasing effectiveness — around 20-30% is effective for most conditions, with very high concentrations reserved for extreme exposure. The practical drawback is that DEET dissolves plastics and synthetic fabrics, which is a real problem around sunglasses, watch bezels, dry bags, and technical clothing.

  2. 2

    Picaridin: comparable protection without dissolving your gear

    Picaridin at 20% provides protection comparable to similar-strength DEET against mosquitoes and ticks. It does not damage plastics or synthetics, has little odour, and feels less greasy. For hikers surrounded by synthetic gear, this is usually the better skin repellent.

    Tick avoidanceBuilding a full prevention approach
    Read Guide →
  3. 3

    Permethrin: clothing only, and it kills rather than repels

    Permethrin is applied to clothing, boots, and gear — never skin — and bonds to fabric through several washes. Ticks that contact treated fabric are killed rather than merely deterred, which is why it is the strongest single measure against tick-borne illness. It must be applied at home and allowed to dry completely before wearing.

  4. 4

    Combine them rather than choosing

    The standard approach for tick country is permethrin on clothing and picaridin or DEET on exposed skin. The two layers address different exposure paths — the clothing treatment catches ticks climbing from vegetation, the skin repellent handles what reaches bare skin.

  5. 5

    Safety points worth taking seriously

    Permethrin is toxic to cats while wet and must be dried fully away from them. Follow label directions for children's use on all three. If you have concerns about a specific product for yourself or a child, the label and a pharmacist or doctor are better sources than a gear site.

Three Products Compared

ProductApplied toWorks byDamages synthetics
Picaridin 20%SkinRepellingNo
DEET 30%SkinRepellingYes
DEET 98%SkinRepelling, longest durationYes
PermethrinClothing onlyKilling on contactNo — bonds to fabric

Frequently Asked Questions

Is higher DEET concentration more effective?
It lasts longer rather than working better. Around 20-30% is effective for typical hiking; very high concentrations mainly extend duration in extreme conditions.
Can I put permethrin on my skin?
No. It is a clothing and gear treatment only. Follow the label, and let treated items dry completely before wearing.
Which is best for ticks?
Permethrin-treated clothing is the strongest single measure, combined with a skin repellent on exposed areas and a thorough tick check after every hike.